蛋白名称
WD repeat-containing protein 81
免疫原
Synthesized peptide derived from human WDR81 AA range: 525-575
特异性
This antibody detects endogenous levels of human WDR81
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains caMABle of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. [provided by RefSeq, Jul 2008],
功能
domain:The SH3 domain interacts with FYB.,function:Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.,PTM:Phosphorylated on tyrosines. Phosphorylation by FYN on Tyr-271 is required for GRB2 interaction. Phosphorylation by FYN on Tyr-295 abolishes interaction with FYB. Tyr-232 is dephosphorylated by PTPRC.,similarity:Belongs to the SKAP family.,similarity:Contains 1 PH domain.,similarity:Contains 1 SH3 domain.,subcellular location:Upon T-cell stimulation, translocates to lipid rafts at the cell membrane.,subunit:Homodimer. Interacts with FYN and PTPRC. Interacts with GRB2 when phosphorylated on Tyr-271. Interacts with F
