基因名称(Gene Name)
DCAF8L2 WDR42C
蛋白名称
DDB1- and CUL4-associated factor 8-like protein 2 (WD repeat-containing protein 42C)
免疫原
Synthesized peptide derived from human DC8L2 AA range: 458-508
特异性
This antibody detects endogenous levels of human DC8L2
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted, and is abundantly found in plasma. Downregulation of expression of this gene by promoter hypermethylation has been observed in a wide spectrum of human malignancies, including thyroid cancer, hepatocellular carcinoma and chronic myeloid leukemia. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designa
功能
catalytic activity:2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.,function:Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.,online information:Glutathione peroxidase entry,PTM:The N-terminus is blocked.,similarity:Belongs to the glutathione peroxidase family.,subunit:Homotetramer.,tissue specificity:Secreted in plasma.,
