基因名称(Gene Name)
C10orf107
蛋白名称
Uncharacterized protein C10orf107
免疫原
Synthesized peptide derived from human CJ107 AA range: 7-57
特异性
This antibody detects endogenous levels of human CJ107
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. The encoded protein also has a peptide that displays antimicrobial activity against C. albicans, E. coli, S. aureus, P. aeruginosa, and E. faecalis. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels. [provided by RefSeq, Nov 2014],
功能
domain:In addition to having a high His and Pro content, this protein has many internal repeats. 12 tandem repetitions of a 5-residue sequence (GHHPH, consensus) form a histidine-rich region.,function:The physiological function is not yet known. It binds heme, dyes and divalent metal ions. It can inhibit rosette formation and is known to interact with heparin, thrombospondin, and the lysine-binding site of plasminogen. On the basis of its homology with HMW kininogen, the His-rich region of this protein may mediate the contact activation phase of intrinsic blood coagulation cascade.,similarity:Contains 2 cystatin domains.,tissue specificity:Expressed by the liver and secreted in plasma.,
