蛋白名称
THUMP domain-containing protein 3
免疫原
Synthesized peptide derived from human THUM3 AA range: 410-460
特异性
This antibody detects endogenous levels of human THUM3
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
The protein encoded by this gene is a leucine zipper-containing transcriptional coactivator that may link the upstream activator ATF2 with the basal transcription complex. The encoded protein is closely associated with chromatin and is required for the proper differentiation of embryonic carcinoma and embryonic stem cells. Found nearly exclusively in pluripotent cells, this protein can also serve as a transcriptional repressor. [provided by RefSeq, Nov 2015],
功能
domain:The leucine-zipper domain is required for coactivation activity. When this domain is deleted, the protein is able to stimulate transcription from a number of gene promoters.,function:Acts as a transcriptional coactivator of ATF2.,PTM:Phosphorylated.,subunit:Binds to the N-terminal region of ATF2. Associates with the TFIID complex through interaction with TBP.,
