基因名称(Gene Name)
CELA3A ELA3 ELA3A
蛋白名称
Chymotrypsin-like elastase family member 3A (EC 3.4.21.70) (Elastase IIIA) (Elastase-3A) (Protease E)
免疫原
Synthesized peptide derived from human CEL3A AA range: 29-79
特异性
This antibody detects endogenous levels of human CEL3A
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kapMAB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008],
功能
disease:Most specific Hodgkin disease associated antigen.,function:Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.,PTM:Phosphorylated on serine and tyrosine residues.,similarity:Contains 6 TNFR-Cys repeats.,subunit:Interacts with TRAF1, TRAF2, TRAF3 and TRAF5.,
