基因名称(Gene Name)
TCP10L PRED77
蛋白名称
T-complex protein 10A homolog 2 (T-complex protein 10A-2) (TCP10A-2) (TCP10-like)
免疫原
Synthesized peptide derived from human TCP1L AA range: 68-118
特异性
This antibody detects endogenous levels of human TCP1L
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008],
功能
function:Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release.,similarity:Contains 1 BAG domain.,subunit:Binds to the ATPase domain of HSP70/HSC chaperones.,
