基因名称(Gene Name)
CDC20B G6VTS76519
蛋白名称
Cell division cycle protein 20 homolog B
免疫原
Synthesized peptide derived from human CD20B AA range: 157-207
特异性
This antibody detects endogenous levels of human CD20B
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],
功能
domain:The PHD-type zinc finger domain binds to phosphoinositides (PtdInsPs), including phosphatidylinositol 5-phosphate (PtdIns(5)P).,function:Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).,induction:Induced by the DNA-damaging agents etoposide and neocarzinostatin.,similarity:Belongs to the ING family.,similarity:Contains 1 PHD-type zinc finger.,subcellular location:Predominantly nuclear. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm.,subunit:Component of a mSin3A-like complex at least cons
