基因名称(Gene Name)
MIS18BP1 C14orf106 KIAA1903 KNL2 M18BP1
蛋白名称
Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243)
免疫原
Synthesized peptide derived from human M18BP AA range: 929-979
特异性
This antibody detects endogenous levels of human M18BP
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protein tyrosine kinases to regulate their activity. [provided by RefSeq, Jun 2016],
功能
function:Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.,similarity:Belongs to the PI3K p85 subunit family.,similarity:Contains 2 SH2 domains.,subunit:Heterodimer of a p110 (catalytic) and a p55 (regulatory) subunits.,tissue specificity:Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle.,
