基因名称(Gene Name)
TRUB1 PUS4
蛋白名称
Probable tRNA pseudouridine synthase 1 (EC 5.4.99.-)
免疫原
Synthesized peptide derived from human TRUB1 AA range: 116-166
特异性
This antibody detects endogenous levels of human TRUB1
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Oct 2010],
功能
function:Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner.,similarity:Belongs to the ORC5 family.,subunit:ORC is composed of six subunits.,
