基因名称(Gene Name)
PTPLAD1 BIND1 HACD3
免疫原
Synthesized peptide derived from human HACD3 AA range: 255-305
特异性
This antibody detects endogenous levels of HACD3 at Human/Mouse
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013],
功能
function:Involved in Rac1-signaling pathways leading to the modulation of gene expression.,induction:By AKAP12 and histone deacetylase inhibitors such as sodium butyrate.,similarity:Belongs to the PTPLA family.,similarity:Contains 1 CS domain.,subunit:Interacts with RAC1.,tissue specificity:Highly expressed in testis, kidney, brain, liver and weakly in skeletal muscle, spleen and heart.,
