基因名称(Gene Name)
DZIP1 DZIP DZIP2 KIAA0996
免疫原
Synthesized peptide derived from human DZIP1 AA range: 73-123
特异性
This antibody detects endogenous levels of DZIP1 at Human/Mouse
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
function:IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein.,induction:Down-regulated in multiple tumors.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 IGFBP N-terminal domain.,similarity:Contains 1 Kazal-like domain.,tissue specificity:Expressed at the highest level in both brain and testis, with lower levels in the prostate, bladder and lung.,
功能
function:May participate in spermatogenesis via its interaction with DAZ.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the DZIP C2H2-type zinc-finger protein family.,similarity:Contains 1 C2H2-type zinc finger.,subcellular location:In testis, it is predominantly nuclear, with some cytoplasmic localization in spermatogonia. Colocalizes with DAZ and DAZL in primordial germ cells.,subunit:Isoform 1 and isoform 2 interact with DAZ proteins. May participate in a RNA-binding complex that functions in both ES cells and germ cells.,tissue specificity:Predominantly expressed in testis. Also expressed in fetal brain, adult oocytes and ovary. Expressed in undifferentiated ES cells. In testis, it is probably specifically expressed in germ cells. Expressed in mature germ cells and secondary spermatocytes, while it is weakly or not expressed in primary sper
