免疫原
Synthesized peptide derived from human TM136 AA range: 77-127
特异性
This antibody detects endogenous levels of TM136 at Human/Mouse
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4(CITED4) Homo sapiens The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors. [provided by RefSeq, Aug 2011],
功能
similarity:Belongs to the TMEM136 family.,similarity:Contains 1 TLC (TRAM/LAG1/CLN8) domain.,
