首页 / 产品中心 / 单克隆抗体 /

KR111 mouse mAb

文献引用 (0) 说明书 联系我们
货号: YP-mAb-09039
促销价：

产品介绍

反应种属
Human;Rat;Mouse;
应用范围
WB
抗体类型
单克隆抗体
基因名称(Gene Name)
KRTAP11-1 KAP11.1 KRTAP11.1
蛋白名称
KR111
分子量（DA）
免疫原
Synthesized peptide derived from human KR111 AA range: 50-100
特异性
This antibody detects endogenous levels of KR111 at Human
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源
Monoclonal, Mouse,IgG
稀释比例
WB 1:500-2000
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
浓度
1 mg/ml
储存
-20°C/1 year
其他名称
背景
domain:The CCHC-type zinc fingers 1, 5, 6 and 9 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC-type zinc finger is essential for the interaction with GATA-type zinc fingers.,function:Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the FOG (Friend of GATA) family.,similarity:Contains 4 C2H2-type zinc fingers.,similarity:Contains 5 C2HC-type zinc fingers.,subunit:Interacts with corepressor CTBP2; this interaction is however not essential for corepressor activity (By similarity). Interacts with the N-terminal zinc-finger of GATA1, GATA2 and probably GATA3.,tissue specificity:Mainly expressed in hematopoietic tissues. Also expressed in adult cerebellum, stomach, lymph node, liver and pancreas. Expressed in fetal heart, liver and spleen.,
功能
function:In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.,similarity:Belongs to the PMG family.,tissue specificity:Expressed in the upper matrix and in the entire hair cortex.,

展开

产品详情

客户数据及评论 (0)

折叠内容

文献引用

折叠内容

FAQ

折叠内容

优品生物的抗体，可以回收利用几次？

首先，一般抗体不推荐客户回收利用，抗体使用之后缓冲体系已经发生改变，不同客户在回收抗体的保存条件上也会有差异，所以抗体回收使用效果无法保证。另外，优品生物也做过一批抗体回收验证测试，测试结果显示不同抗体可回收次数不同，一般效价越高的抗体，可重复使用的次数越多，客户可根据实验情况来确定。
注：我们将孵育完毕后剩余的抗体回收到离心管中置于4℃保存，效价高的抗体可至少保存1周，至少重复利用3次。

收起

优品生物作为国产抗体品牌的优势？

优品生物是国产品牌，通过聚焦抗体与酶核心技术，致力于打破国际技术的垄断，我们拥有包括兔多克隆抗体、小鼠单克隆抗体、兔单克隆抗体的生产研发平台，同时也有包括WB,IP在内的检测平台，我们对每一支自产的抗体进行了严格的检测。当然，我们部分直销地区也可以帮客户代购进口品牌的产品。同时也有抗体定制服务。优品生物l抗体优势：1，严自检，保质量；2产品多，指标全；3，价格低，货期短。

收起

优品生物抗体成分？

优品生物抗体成分在平时工作当中，常会有客户咨询我们的抗体用的什么buffer进行保存，一般来说，我们的buffer的成分是：PBS含0.03%的proclin300、0.05%牛血清白蛋白、50%甘油；也有一些是PBS含0.03%的proclin300，50%甘油。防腐剂 Proclin 300活性成分主要是2-甲基-4-异噻唑啉-3-酮（MCI）和5-氯-2-甲基-4-异噻唑啉-3-酮（CMCI）。ProClin生物灭活剂能够迅速穿透细胞膜，抑制对细胞呼吸至关重要的特定酶，因此一接触微生物有机体就会立即抑制细胞活性。ProClin的多个特定毒性位点可以防止微生物产生高水平的耐药性。

收起

实验方案

折叠内容
>