基因名称(Gene Name)
KRTAP5-9 KAP5.9 KRN1 KRTAP5.9 UHSK1
免疫原
Synthesized peptide derived from human KRA59 AA range: 9-59
特异性
This antibody detects endogenous levels of KRA59 at Human
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
This gene is similar to a mouse gene that encodes a TATA box binding protein-associated factor, and shows testis-specific expression. The encoded protein could be a spermatogenesis-specific component of the DNA-binding general transcription factor complex TFIID. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009],
功能
developmental stage:At a late stage of fiber differentiation.,function:In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.,similarity:Belongs to the KRTAP type 5 family.,subunit:Interacts with hair keratins.,tissue specificity:Restricted to hair root, not detected in any other tissues. Expressed in cuticle layers of differentiating hair follicles.,
