基因名称(Gene Name)
CYP4A11 CYP4A2
免疫原
Synthesized peptide derived from human CP4AB AA range: 389-439
特异性
This antibody detects endogenous levels of CP4AB at Human
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
cytochrome P450 family 4 subfamily A member 11(CYP4A11) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016],
功能
catalytic activity:Octane + reduced rubredoxin + O(2) = 1-octanol + oxidized rubredoxin + H(2)O.,cofactor:Heme group.,function:Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE).,online information:CYP4A11 alleles,polymorphism:CYP4A11v seems to be a rare allelic variant of CYP4A11, it seems to be unstable and not to metabolize lauric acid.,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Kidney and liver.,
