基因名称(Gene Name)
RHBDL3 RHBDL4 VRHO
免疫原
Synthesized peptide derived from human RHBL3 AA range: 31-81
特异性
This antibody detects endogenous levels of RHBL3 at Human/Mouse
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
The protein encoded by this gene is a component of an E3 ubiquitin-protein ligase complex. The encoded protein interacts with TP53, CUL9, and FBXW8 proteins. Defects in this gene are a cause of 3M syndrome type 1 (3M1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009],
功能
catalytic activity:Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.,function:May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.,similarity:Belongs to the peptidase S54 family.,similarity:Contains 2 EF-hand domains.,
