背景
zinc finger protein 335(ZNF335) Homo sapiens The protein encoded by this gene enhances transcriptional activation by ligand-bound nuclear hormone receptors. However, it does this not by direct interaction with the receptor, but by direct interaction with the nuclear hormone receptor transcriptional coactivator NRC. The encoded protein may function by altering local chromatin structure. [provided by RefSeq, Jul 2008],
功能
function:May regulate transcriptional activation through NCOA6.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 13 C2H2-type zinc fingers.,subunit:Interacts with NCOA6, but not with ligand-bound nuclear hormone receptors, including ESR1, THRA, RARA, RXRA, GCCR and PPARA.,tissue specificity:Relatively high expression in the skeletal muscle, thymus, placenta and blood. Moderate expression in the colon, kidney and lung. Low expression in the small intestine, heart, liver and brain.,
