基因名称(Gene Name)
IGHV4OR15-8 VSIG6
免疫原
Synthesized peptide derived from human IV4F8 AA range: 36-86
特异性
This antibody detects endogenous levels of IV4F8 at Human
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011],
功能
domain:Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands.,function:Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.,similarity:Belongs to the eukaryotic mitochondrial porin family.,tissue specificity:Widely expressed. Highest in testis.,
