基因名称(Gene Name)
LOXL3 LOXL
免疫原
Synthesized peptide derived from human LOXL3 AA range: 130-180
特异性
This antibody detects endogenous levels of LOXL3 at Human/Mouse
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
This gene encodes a lysyl oxidase, which likely functions as an amine oxidase and plays a role in the formation of crosslinks in collagens and elastin. Deletion of the related gene in mouse causes neonatal mortality with cleft palate, spine deformity, and defects in collagen organization. A mutation in this gene was found in a family with Stickler syndrome. [provided by RefSeq, Sep 2016],
功能
cofactor:Contains 1 lysine tyrosylquinone.,cofactor:Copper.,PTM:The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.,similarity:Belongs to the lysyl oxidase family.,similarity:Contains 4 SRCR domains.,tissue specificity:Expressed in many tissues, the highest levels among the tissues studied being seen in the placenta, heart, ovary, testis, small intestine and spleen.,
