基因名称(Gene Name)
CLVS2 C6orf212 C6orf213 RLBP1L2
免疫原
Synthesized peptide derived from human CLVS2 AA range: 26-76
特异性
This antibody detects endogenous levels of CLVS2 at Human/Mouse/Rat
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
This gene encodes a protein that belongs to the SEC14/CRAL-TRIO family of proteins. A similar protein in rat is thought to function in the endosomal pathway between early endosomes and mature lysosomes. [provided by RefSeq, Aug 2013],
功能
alternative products:Named isoforms=3,function:Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the ubiquitin-activating E1 family.,tissue specificity:Widely expressed. Isoform 2 is predominantly expressed in testis with higher expression in adult testis than in fetal testis.,
