基因名称(Gene Name)
UNC93B1 UNC93 UNC93B
免疫原
Synthesized peptide derived from human UN93B AA range: 347-397
特异性
This antibody detects endogenous levels of UN93B at Human/Mouse
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
This gene encodes a protein that is involved in innate and adaptive immune response by regulating toll-like receptor signaling. The encoded protein traffics nucleotide sensing toll-like receptors to the endolysosome from the endoplasmic reticulum. Deficiency of the encoded protein has been associated with herpes simplex encephalitis. [provided by RefSeq, Feb 2014],
功能
disease:Defects in UNC93B1 are associated with susceptibility to herpes simplex encephalitis (HSE) [MIM:610551]. HSE is a rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. UNC93B-deficient HSE does not compromise immunity to most pathogens, unlike most known primary immunodeficiencies.,online information:UNC93B1 mutation db,similarity:Belongs to the unc-93 family.,tissue specificity:Expressed in heart, heart, and at lower level in kidney. Expressed at low level in other tissues.,
