免疫原
Synthesized peptide derived from human RBY1C AA range: 321-371
特异性
This antibody detects endogenous levels of RBY1C at Human
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
The protein encoded by this gene is an orphan homeobox protein that encodes a DNA-binding nuclear transcription factor. A translocation [t(5;14)(q35;q32)] involving this gene is associated with T-cell acute lymphoblastic leukemia (T-ALL) in children and young adults. [provided by RefSeq, Nov 2015],
功能
developmental stage:Expressed in all of the transcriptionally active stages of germ cell development from spermatogonia through spermatocytes to round spermatids.,function:RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.,miscellaneous:The RBMY1 proteins are encoded by strongly repeated regions of the Y chromosome, mostly within the AZFb region. The exact number of functional copies is unclear and may vary between individues, and some of them may represent pseudogenes. The proteins are very similar, which gives their indidual characterization difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a RBMY1 protein involve all the proteins.,similarity:Contains 1 RRM (RNA recognition motif) domain.,su
