免疫原
Synthesized peptide derived from human TTL AA range: 160-210
特异性
This antibody detects endogenous levels of TTL at Human/Mouse/Rat
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).[supplied by OMIM, Mar 2008],
功能
catalytic activity:ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate.,cofactor:Magnesium.,cofactor:Potassium.,function:Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.,similarity:Belongs to the tubulin--tyrosine ligase family.,similarity:Contains 1 TTL domain.,subunit:Monomer.,
