免疫原
Synthesized peptide derived from human TTC5 AA range: 82-132
特异性
This antibody detects endogenous levels of TTC5 at Human/Mouse/Rat
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
function:May act as a GTPase-activating protein for Rab family protein(s).,similarity:Contains 1 PH domain.,similarity:Contains 1 Rab-GAP TBC domain.,tissue specificity:Expressed in a broad range of tissues. Differentially expressed in prostate normal and cancer cells.,
功能
function:Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2.,PTM:Phosphorylation at Ser-203 enhances protein stability, regulates nuclear accumulation and association with p300/EP300.,similarity:Contains 4 TPR repeats.,subcellular location:Phosphorylation at Ser-203 results in nuclear localization, while unphosphorylated protein localizes to the cytoplasm.,subunit:Interacts with JMY and p300/EP300.,
