背景
domain:The C-terminal domain is essential for the homodimerization and the interaction with CBL. While the interaction with CBL is apparently mediated via the hydrophobic region of this domain, the highly charged region is apparently required for the homodimerization.,function:Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.,induction:By all-trans retinoic acid (ATRA). Induction is indirect and is mediated through other proteins.,PTM:Phosphorylated.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,subcellular location:Colocalizes with endosomes.,subunit:Interacts with EPHA2, VAV1, LCP2 and PDGFRB (By similarity). Homodimer. Homodimerization and interaction with phosphorylated CBL occurs via its C-terminal domain. Interacts with phosphorylated proteins ZAP70, CD3Z, SYK and LAT via its SH2 domain.,tissue specificity:Expressed in lung and fetal brain. Weakly expressed in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas.,
功能
domain:The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.,function:May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.,induction:By FGF signaling.,similarity:Belongs to the sprouty family.,similarity:Contains 1 SPR (sprouty) domain.,subcellular location:Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).,
