基因名称(Gene Name)
VPRBP DCAF1 KIAA0800 RIP
免疫原
Synthesized peptide derived from human VPRBP AA range: 804-854
特异性
This antibody detects endogenous levels of VPRBP at Human/Mouse
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011],
功能
domain:Although not canonical, the WD repeat-like region is related to WD repeats.,function:May act as a receptor for CUL4-DDB1 ubiquitin ligase complex. In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr, possibly leading to hijack the RBX1-CUL4-DDB2 and arrest the cell cycle in G2 phase.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the VPRBP family.,similarity:Contains 1 LisH domain.,subunit:Interacts with DDB1, suggesting that it may participate to some RBX1-CUL4-DDB2 ubiquitin ligase complex. In case of infection, interacts with HIV-1 virus Vpr protein and forms a ternary complex with HIV-1 Vpr and DDB1.,tissue specificity:Ubiquitously expressed.,
