基因名称(Gene Name)
PI4KA PIK4 PIK4CA
免疫原
Synthesized peptide derived from human PI4KA AA range: 1065-1115
特异性
This antibody detects endogenous levels of PI4KA at Human
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. [provided by RefSeq, Sep 2014],
功能
catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.,enzyme regulation:This is a type II PtdIns-4-kinase activated by detergents such as triton and inhibited by adenosine.,function:Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate.,similarity:Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.,similarity:Contains 1 PI3K/PI4K domain.,tissue specificity:Expressed ubiquitously. Highest levels in placenta and brain. Little or no expression in lung, liver, pancreas, testis or leukocytes.,
