免疫原
Synthesized peptide derived from human SAA2 AA range: 36-86
特异性
This antibody detects endogenous levels of SAA2 at Human/Mouse
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are
功能
disease:BOL is from a patient with Waldenstrom macroglobulinemia.,disease:JL is from a patient with ankylosing spondylitis.,disease:Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.,disease:TH is from a patient with juvenile rheumatoid arthritis.,function:Major acute phase reactant. Apolipoprotein of the HDL complex.,induction:Upon cytokine stimulation.,mass spectrometry: PubMed:12606051,mass spectrometry: PubMed:12973732,mass spectrometry:With variant Ala-70 PubMed:1463770,mass spectrometry:With variants Ala-70, Val-75, Asn-78 and 86-Leu-Thr-87 PubMed:1463770,miscellaneous:Elevated serum SSA protein levels may be associated with lung cancer.,polymorphism:Both SAA1 and SAA2 have a number of alleles
