基因名称(Gene Name)
SLC22A16 OCT6
免疫原
Synthesized peptide derived from human S22AG AA range: 49-99
特异性
This antibody detects endogenous levels of S22AG at Human/Mouse
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
This gene encodes a member of the organic zwitterion transporter protein family which transports carnitine. The encoded protein has also been shown to transport anticancer drugs like bleomycin (PMID: 20037140) successful treatment has been correlated with the level of activity of this transporter in tumor cells. [provided by RefSeq, Dec 2011],
功能
function:High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent.,similarity:Belongs to the major facilitator superfamily. Organic cation transporter family.,subcellular location:Detected in the plasma mebrane of Sertoli cells and in the luminal membrane of epithelial cells in the epididymus.,tissue specificity:Widely expressed at low levels in adult tissues and fetal brain, lung, liver and kidney. Expressed in testis and epididymus (at protein level). Expressed at lower levels in bone marrow and fetal liver. Expressed in
