免疫原
Synthesized peptide derived from human SSX6 AA range: 119-169
特异性
This antibody detects endogenous levels of SSX6 at Human
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
This gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also caMABle of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This gene is classified as a pseudogene because a splice donor in the 3' UTR has changed compared to other family members, rendering the transcript a candidate for nonsense-mediated mRNA decay (NMD). [provided by RefSeq, Aug 2009],
功能
function:Could act as a modulator of transcription.,similarity:Belongs to the SSX family.,similarity:Contains 1 KRAB-related domain.,tissue specificity:Not detected in any normal tissues. Expressed in a melanoma cell line.,
