基因名称(Gene Name)
LINC00521 C14orf48
免疫原
Synthesized peptide derived from human CN048 AA range: 33-83
特异性
This antibody detects endogenous levels of CN048 at Human
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport. [provided by RefSeq, Jul 2008],
功能
function:pH-dependent, voltage insensitive, outwardly rectifying potassium channel. Outward rectification is lost at high external K(+) concentrations.,miscellaneous:Inhibited by quinine, quinidine and external acidification.,similarity:Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.,subunit:Homodimer; disulfide-linked.,tissue specificity:Abundant expression in kidney, also detected in liver, placenta and small intestine. In the kidney, expression is restricted to the distal tubules and collecting ducts. Not expressed in proximal tubules or glomeruli.,
