基因名称(Gene Name)
PBXIP1 HPIP
免疫原
Synthesized peptide derived from human PBIP1 AA range: 585-635
特异性
This antibody detects endogenous levels of PBIP1 at Human/Mouse/Rat
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
The protein encoded by this gene interacts with the PBX1 homeodomain protein, inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein, which is primarily cytosolic but can shuttle to the nucleus, also can interact with estrogen receptors alpha and beta and promote the proliferation of breast cancer, brain tumors, and lung cancer. Several transcript variants encoding different isoforms have been found for this gene. More variants exist, but their full-length natures have yet to be determined. [provided by RefSeq, Dec 2015],
功能
domain:Association to the cytoskeleton through a N-terminal leucine rich-domain (AA 190-218).,domain:The C-terminal domain (AA 443-731) contains a nuclear export signal.,function:Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.,subcellular location:Shuttles between the nucleus and the cytosol. Mainly localized in the cytoplasm, associated with microtubules. Detected in small amounts in the nucleus.,subunit:Interacts with ESR1, PBX1, PBX2 and PBX3.,tissue specificity:Expressed in early hematopietic precursors.,
