基因名称(Gene Name)
GOLGA7 GCP16 HDCKB03P HSPC041
免疫原
Synthesized peptide derived from human GOGA7 AA range: 64-114
特异性
This antibody detects endogenous levels of GOGA7 at Human/Mouse/Rat
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
This gene encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. These paraspeckles are composed of RNA-protein structures that include a non-coding RNA, NEAT1/Men epsilon/beta, and the Drosophila Behavior Human Splicing family of proteins, which include the product of this gene and the P54NRB/NONO and PSF/SFPQ proteins. Paraspeckles may function in the control of gene expression via an RNA nuclear retention mechanism. The protein encoded by this gene is found in paraspeckles in transcriptionally active cells, but it localizes to unique cap structures at the nucleolar periphery when RNA polymerase II transcription is inhibited, or during telophase. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene, which is also located on chromosome 13, has been identified. [provided by
功能
function:May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS.,PTM:Palmitoylated on Cys-69 and Cys-72; which is required for Golgi localization and interaction with GOLGA3.,similarity:Belongs to the ERF4 family.,subunit:Interacts with GOLGA3. Interacts with ZDHHC9.,tissue specificity:Expressed in all tissues except colon and thymus.,
