基因名称(Gene Name)
ADPRM C17orf48 MDS006 Nbla03831
免疫原
Synthesized peptide derived from human ADPRM AA range: 225-275
特异性
This antibody detects endogenous levels of ADPRM at Human/Mouse/Rat
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
nucleoporin 214(NUP214) Homo sapiens The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015],
功能
catalytic activity:ADP-ribose + H(2)O = AMP + D-ribose 5-phosphate.,catalytic activity:CDP-choline + H(2)O = CMP + phosphocholine.,catalytic activity:CDP-glycerol + H(2)O = CMP + sn-glycerol 3-phosphate.,cofactor:Magnesium.,function:hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress.,similarity:Belongs to the ADPRibase-Mn family.,subunit:Monomer.,
