基因名称(Gene Name)
ZNF146 OZF
免疫原
Synthesized peptide derived from human OZF AA range: 3-53
特异性
This antibody detects endogenous levels of OZF at Human/Mouse
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. A mutation in this gene results in inclusion body myopathy-3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2009],
功能
miscellaneous:Strongly overexpressed in many pancreas and colorectal cancers. Increased gene copy numbers are detected in 3 of 12 tumor cell lines and 2 of 12 primary pancreatic carcinomas. Overexpresseed in 80% of colorectal cancers.,PTM:Sumoylated.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 10 C2H2-type zinc fingers.,subunit:Binds DNA. Interacts with SUMO conjugating enzyme UBC9/UBE2I. Interacts with the telomeric protein TERF2IP.,tissue specificity:Liver, skeletal and heart muscle, mammary cells. Very low levels in brain, lung, placenta and kidney.,
