免疫原
Synthesized peptide derived from human PANK4 AA range: 8-58
特异性
This antibody detects endogenous levels of PANK4 at Human/Mouse/Rat
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.351% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
其他名称
Pantothenate kinase 4 (hPanK4) (EC 2.7.1.33) (Pantothenic acid kinase 4)
背景
This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is most abundant in muscle but is expressed in all tissues. [provided by RefSeq, Jul 2008],
功能
catalytic activity:ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.,enzyme regulation:Regulated by feedback inhibition by CoA and its thioesters.,function:Plays a role in the physiological regulation of the intracellular CoA concentration.,pathway:Cofactor biosynthesis; coenzyme A biosynthesis; coenzyme A from pantothenate: step 1/5.,similarity:Belongs to the type II pantothenate kinase family.,subunit:Interacts with PKM2.,tissue specificity:Ubiquitously expressed with higher expression in the muscle.,
