基因名称(Gene Name)
CMIP KIAA1694 TCMIP
免疫原
Synthesized peptide derived from human CMIP AA range: 105-155
特异性
This antibody detects endogenous levels of CMIP at Human/Mouse
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.345% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
其他名称
C-Maf-inducing protein (c-Mip) (Truncated c-Maf-inducing protein) (Tc-Mip)
背景
This gene encodes a c-Maf inducing protein that plays a role in T-cell signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011],
功能
developmental stage:Expressed in fetal liver.,disease:Isoform 2 expression is up-regulated in MCNS.,function:Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.,similarity:Contains 1 PH domain.,subcellular location:Isoform 2 is translocated to the nucleus and is specifically recruited during minimal change nephrotic syndrome (MCNS). Detected in nuclear and cytoplasmic compartments during MCNS relapse. Expressed in cytoplasm only during MCNS remission and absent in normal patients.,subunit:Interacts with FLNA.,tissue specificity:Isoform 1 is expressed in peripheral blood mononuclear cells and kidney. Lower expression in brain and liver. Expression is down-regulated in activated cells. Is
