免疫原
Synthesized peptide derived from human K1751 AA range: 315-365
特异性
This antibody detects endogenous levels of K1751 at Human/Mouse
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.297% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
其他名称
Uncharacterized protein KIAA1751
背景
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the
功能
polymorphism:PubMed:11214970 sequence (BAB21842) differs from that shown due to a possible polymorphism in position 763 that produces a Gln residue instead of a stop codon (dbSNP:rs28548017) and leads to a protein of 768 residues whose C-terminal sequence is Ser-Gln-Ala-Phe-Asp-Val-Lys instead of Ser.,
