基因名称(Gene Name)
SKOR1 CORL1 FUSSEL15 LBXCOR1
免疫原
Synthesized peptide derived from human SKOR1 AA range: 322-372
特异性
This antibody detects endogenous levels of SKOR1 at Human/Mouse/Rat
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.272% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
其他名称
SKI family transcriptional corepressor 1 (Functional Smad-suppressing element on chromosome 15) (Fussel-15) (LBX1 corepressor 1) (Ladybird homeobox corepressor 1)
背景
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. Mutations in this particular gene cause synpolydactyly. [provided by RefSeq, Jul 2008],
功能
caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Acts as a transcriptional corepressor of LBX1 (By similarity). Inhibits BMP signaling.,similarity:Belongs to the SKI family.,subunit:Interacts with LBX1 (By similarity). Interacts with SMAD1, SMAD2 and SMAD3.,tissue specificity:Present specifically in cerebellar Purkinje cells (at protein level).,
