基因名称(Gene Name)
KIF5B KNS KNS1
免疫原
Synthesized peptide derived from human KINH AA range: 64-114
特异性
This antibody detects endogenous levels of KINH at Human/Mouse/Rat
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.266% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
其他名称
Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC)
背景
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene binds to a promoter element of the lactase-phlorizin hydrolase. It also may play a role in early intestinal development. An alternatively spliced variant encoding a shorter isoform has been described but its full-length nature has not been determined. [provided by RefSeq, Jul 2008],
功能
domain:Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.,function:Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes.,similarity:Belongs to the kinesin-like protein family.,similarity:Belongs to the kinesin-like protein family. Kinesin subfamily.,similarity:Contains 1 kinesin-motor domain.,subcellular location:Uniformly distributed between soma and neurites in hippocampal neurons.,subunit:Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1 (By similarity). Interacts with
