免疫原
Synthesized peptide derived from human POK6 AA range: 691-741
特异性
This antibody detects endogenous levels of POK6 at Human
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.243% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
其他名称
HERV-K_8p23.1 provirus ancestral Pol protein (HERV-K115 Pol protein) [Includes: Reverse transcriptase (RT) (EC 2.7.7.49); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN)]
背景
The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010],
功能
domain:In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.,domain:The basic domain (B) allows nucleolar localization in the absence of GTP. The intermediate domain (I) inhibits nucleolar localization by the B domain and is required for exit from the nucleolus. Exit from the nucleolus to the nucleoplasm requires both the I and the acidic (A) domains, and may be triggered by GTP hydrolysis.,function:May be required to maintain the proliferative capacity of stem cells and may play an important role in tumorigenesis.,similarity:Belongs to the MMR1/HSR1 GTP-binding protein family.,subcellular location:Shuttles between the nucleus and nucleolus.,subunit:May interact with p53/TP53 via its basic domain.,tissue specificity:Increased levels in lung tissue in cancer patients.,
