基因名称(Gene Name)
CFHR5 CFHL5 FHR5
免疫原
Synthesized peptide derived from human FHR5 AA range: 353-403
特异性
This antibody detects endogenous levels of FHR5 at Human
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.165% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
其他名称
Complement factor H-related protein 5 (FHR-5)
背景
This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS). [provided by RefSeq, Jan 2010],
功能
function:Involved in complement regulation.,similarity:Contains 9 Sushi (CCP/SCR) domains.,subunit:Binds C3b in vitro.,tissue specificity:Expressed by the liver and secreted in plasma.,
