免疫原
Synthesized peptide derived from human CR1L AA range: 45-95
特异性
This antibody detects endogenous levels of CR1L at Human/Mouse/Rat
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.163% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
其他名称
Complement component receptor 1-like protein (Complement C4b-binding protein CR-1-like protein)
背景
function:E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 C2 domain.,similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.,similarity:Contains 2 WW domains.,subunit:Interacts with DVL1 and SSR3. Also interacts with mutant SOD1.,tissue specificity:Predominantly expressed in neurons of adult and fetal brain. Weakly expressed in the kidney.,
功能
similarity:Belongs to the receptors of complement activation (RCA) family.,similarity:Contains 8 Sushi (CCP/SCR) domains.,subcellular location:Predominantly found in association with the membrane fraction, but also located in the cytoplasm and in the supernatant.,subunit:Interacts with iC4 (methylamine-treated C4) but not for iC3 (methylamine-treated C3).,tissue specificity:Expressed in fetal liver and to a lesser extent in fetal spleen and thymus. Expression appears to be limited to hematopoietic and fetal lymphoid tissue.,
