基因名称(Gene Name)
SGPL1 KIAA1252
免疫原
Synthesized peptide derived from human SGPL1 AA range: 393-443
特异性
This antibody detects endogenous levels of SGPL1 at Human/Mouse/Rat
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.158% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
其他名称
Sphingosine-1-phosphate lyase 1 (S1PL) (SP-lyase 1) (SPL 1) (hSPL) (EC 4.1.2.27) (Sphingosine-1-phosphate aldolase)
背景
dynein light chain Tctex-type 1(DYNLT1) Homo sapiens This gene encodes a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. The encoded protein regulates the length of primary cilia which are sensory organelles found on the surface of cells. The protein encoded by this gene interacts with viral proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation. Pseudogenes of this gene are present on chromosomes 4 and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014],
功能
catalytic activity:Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde.,cofactor:Pyridoxal phosphate.,function:Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.,pathway:Lipid metabolism; sphingolipid metabolism.,similarity:Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.,tissue specificity:Found in liver and kidney.,
