基因名称(Gene Name)
SLC11A2 DCT1 DMT1 NRAMP2 OK/SW-cl.20
免疫原
Synthesized peptide derived from human NRAM2 AA range: 474-524
特异性
This antibody detects endogenous levels of NRAM2 at Human/Mouse/Rat
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.156% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
其他名称
Natural resistance-associated macrophage protein 2 (NRAMP 2) (Divalent cation transporter 1) (Divalent metal transporter 1) (DMT-1)
背景
This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010],
功能
disease:Defects in SLC11A2 are a cause of hypochromic microcytic anemia [MIM:206100]. The disease is characterized by an abnormal hemoglobin content in the erythrocytes which are reduced in size. It may be hereditary or acquired. Mutations in SLC11A2 are associated with progressive liver iron overload and normal to moderately elevated serum ferritin levels.,function:Macrophage-specific membrane transport. Important in metal transport, in particular iron.,similarity:Belongs to the NRAMP family.,tissue specificity:Expressed at low levels in all tissues analyzed.,
