基因名称(Gene Name)
MLLT3 AF9 YEATS3
免疫原
Synthesized peptide derived from human AF9 AA range: 328-378
特异性
This antibody detects endogenous levels of AF9 at Human/Mouse
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.153% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
其他名称
Protein AF-9 (ALL1-fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3)
背景
The protein encoded by this gene is a component of the RNA polymerase I and RNA polymerase III complexes, which function in the synthesis of ribosomal RNA precursors and small RNAs, respectively. Mutations in this gene are a cause of Treacher Collins syndrome (TCS), a craniofacial development disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2011],
功能
disease:A chromosomal aberration involving MLLT3 is associated with acute leukemias. Translocation t(9;11)(p22;q23) with MLL/HRX. The result is a rogue activator protein.,similarity:Contains 1 YEATS domain.,subunit:Interacts with BCOR. Interacts with CBX8.,
