免疫原
Synthesized peptide derived from human PGTA AA range: 312-362
特异性
This antibody detects endogenous levels of PGTA at Human/Mouse/Rat
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.146% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
其他名称
Geranylgeranyl transferase type-2 subunit alpha (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit alpha) (Rab geranyl-geranyltransferase subunit alpha) (Rab GG transferase alpha) (Rab GGTase alpha) (Rab geranylgeranyltransferase subunit alpha)
背景
This gene encodes the fourth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit is associated with the polymerase under suboptimal growth conditions and may have a stress protective role. A sequence for a ribosomal pseudogene is contained within the 3' untranslated region of the transcript from this gene. [provided by RefSeq, Jul 2008],
功能
catalytic activity:Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.,cofactor:Binds 1 zinc ion per dimer.,enzyme regulation:The enzymatic reaction requires the aid of a Rab escort protein (also called component A).,function:Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively.,similarity:Belongs to the protein prenyltransferase subunit alpha family.,similarity:Contains 6 PFTA repeats.,subunit:Heterodimer of an alpha and a beta subunit, collectively called component B.,
