基因名称(Gene Name)
NPNT EGFL6L POEM UNQ295/PRO334
免疫原
Synthesized peptide derived from human NPNT AA range: 485-535
特异性
This antibody detects endogenous levels of NPNT at Human/Mouse
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.126% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
其他名称
Nephronectin (Preosteoblast EGF-like repeat protein with MAM domain) (Protein EGFL6-like)
背景
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members in this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. [provided by RefSeq, Apr 2016],
功能
developmental stage:Expressed in fetal kidney, cochlea, eye, heart and lung.,domain:The MAM domain is required for localization at the cell surface.,function:Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins.,similarity:Belongs to the nephronectin family.,similarity:Contains 1 MAM domain.,similarity:Contains 5 EGF-like domains.,subcellular location:Trapped on the cell surface or in the extracellular matrix.,subunit:Homodimer and homotrimer.,tissue specificity:Expressed in kidney and lung and to a lower extent in brain, pregnant uterus, placenta, thyroid gland and blood vessels.,
