免疫原
Synthesized peptide derived from human S2610 AA range: 295-345
特异性
This antibody detects endogenous levels of S2610 at Human/Mouse
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.111% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
其他名称
Solute carrier family 26 member 10
背景
This gene encodes a member of the cyclic nucleotide-gated cation channel protein family which is required for normal vision and olfactory signal transduction. Mutations in this gene are associated with achromatopsia (rod monochromacy) and color blindness. Two alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008],
功能
caution:According to PubMed:12759755, it is a transcribed pseudogene. They however do not provide experimental evidences to support this affirmation.,domain:The guanine nucleotide exchange activity is autoinhibited by the PH domain.,function:Chloride/bicarbonate exchanger.,function:May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis.,similarity:Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain
