基因名称(Gene Name)
FAM114A1 NOXP20
免疫原
Synthesized peptide derived from human NXP20 AA range: 135-185
特异性
This antibody detects endogenous levels of NXP20 at Human/Mouse
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.110% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
其他名称
Protein NOXP20 (Nervous system overexpressed protein 20) (Protein FAM114A1)
背景
hydroxysteroid 11-beta dehydrogenase 2(HSD11B2) Homo sapiens There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mine
功能
function:May play a role in neuronal cell development.,similarity:Belongs to the FAM114 family.,
